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. 2006 Dec 4;27(4):1264–1270. doi: 10.1128/MCB.01888-06

FIG. 6.

FIG. 6.

Inhibition of L1 retrotransposition during replicative senescence. (A) Growth curve for IMR-90 normal human fibroblasts. Open circles represent passages at which L1 retrotransposition was analyzed. (B) Retrotransposition frequency in IMR-90 cells of different replicative ages. The cells were transfected with an L1 retrotransposition cassette and analyzed by flow cytometry on day 5 after transfection. Retrotranspostion frequency was calculated as the ratio of GFP-positive cells obtained in transfection with L1 to GFP-positive cells obtained in transfection with pEGFP vector × 10,000 cells. All the experiments were repeated at least three times, and error bars represent standard deviations.