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Phenotypes associated with Sulf2−/− homozygous mice in a mixed genetic background (N2; 129P2/Ola × C57BL/6). (A) At 41.5 days (d), Sulf2−/− homozygous mice weighed less then their wild-type (WT) littermates. (B) Sulf2−/− animals were occasionally runted from birth. (C) Severely runted Sulf2−/− pups displayed an incompletely penetrant lung phenotype, including enlarged air spaces. Bars, 1 cm (B) and 400 μm (C).
