TABLE 1.

Embryonic expression of Sulf1 and Sulf2 inferred from RNA in situ hybridization^a

Testing site	Sulf1 expression	Sulf2 expression	Commentsb
Dorsal root ganglion	−	+++	A
Notochord	−	++	A
Telencephalic vesicle	+++	++	B
Choroid plexus	+++	++	C
Hindbrain	+++	+	D
Somites	−	+++	A
Floor plate	+++	+++	D
Roof plate	−	++	A
Olfactory epithelium	++	−	A
Eye	++	++	B
Kidney	+	++	A
Liver	−	−	A
Adrenal gland	+	++	D
Testes	+	++	B
Diaphragm	++	+	D
Heart	+	++	A
Cartilage	+	+++	B
Lung	+	++	A
Intestine	+	+++	D
Stomach	++	+++	B
Tooth bud	−	−	A
Ear	+++	−	A
Skin	++	++	D
Tongue	+	+++	B
First branchial arch	+	++	D
Placenta (maternal)	−	++	A
Placenta (embryonic)	−	+++	A
Tip of genital tubercle	+++	+++	D

^a−, no detectable expression; +, low level of expression; ++, medium level of expression; +++, high level of expression. The level of expression is estimated with respect to the signal intensity of each probe separately.

^bA, little or no overlapping expression; B, Sulf1 expression restricted to regions of Sulf2 expression; C, Sulf2 expression restricted to regions of Sulf2 expression; D, significant overlap of Sulf1 and Sulf2 expression.