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. 2006 Apr 17;203(4):843–849. doi: 10.1084/jem.20051496

Figure 3.

Figure 3.

Endogenous IL-25 is required for resistance to Trichuris. (A) IL-25 is required for optimal production of TH2 cytokines after infection. IL-4, IL-13, and IFN-γ expression in the mLN and cecum in WT and IL-25−/− mice at day 18 after infection as measured by real-time PCR. (B) Defective goblet cell responses in IL-25−/− mice after infection with Trichuris. Cecal sections from day 18 infected WT or IL-25−/− mice were stained for goblet cells. Bar, 50 μm. (C) IL-25−/− mice fail to up-regulate RELMβ after infection. Protein isolated from fecal pellets on various days after infection was analyzed by SDS-PAGE and immunoblotted for RELMβ. (D) IL-25 is required for resistance to infection with Trichuris. Worm burdens in WT, IL-25−/− and RAG−/− mice at day 30 after infection. Data are presented as mean ± SEM and are representative of four independent experiments with three to four mice per group. N, naive; I, infected.