Table 2.
Adjusted Mean Percent Densities (%) by Genotype*
| CYP1A2 | N# | N## | Density | COMT | N# | N## | Density | |
| All | AA | 863 | 285 | 27.8 | Val/Val | 688 | 229 | 28.6 |
| AC | 750 | 254 | 29.7 | Val/Met | 780 | 257 | 29.1 | |
| CC | 109 | 36 | 32.9 | Met/Met | 254 | 89 | 29.4 | |
| P (trend)‡ | - | - | 0.11 | P (trend)‡ | - | - | 0.70 | |
| Controls | AA | 315 | 124 | 22.4 | Val/Val | 235 | 95 | 23.6 |
| AC | 253 | 108 | 25.4 | Val/Met | 264 | 108 | 24.6 | |
| CC | 46 | 18 | 31.3 | Met/Met | 115 | 47 | 25.1 | |
| P (trend)‡ | - | - | 0.045 | P (trend)‡ | - | - | 0.61 | |
| Cases | AA | 548 | 161 | 31.1 | Val/Val | 453 | 134 | 31.4 |
| AC | 497 | 146 | 31.4 | Val/Met | 516 | 149 | 31.5 | |
| CC | 63 | 18 | 32.0 | Met/Met | 139 | 42 | 30.3 | |
| P (trend)‡ | - | - | 0.86 | P (trend)‡ | - | - | 0.84 | |
| Premenopausal | AA | 154 | 71 | 35.2 | Val/Val | 125 | 62 | 35.7 |
| AC | 129 | 60 | 36.1 | Val/Met | 124 | 55 | 37.8 | |
| CC | 9 | 4 | 44.8 | Met/Met | 43 | 18 | 30.8 | |
| P (trend)‡ | - | - | 0.38 | P (trend)‡ | - | - | 0.60 | |
| Postmenopausal | AA | 652 | 189 | 25.9 | Val/Val | 523 | 150 | 26.5 |
| AC | 566 | 170 | 27.4 | Val/Met | 596 | 174 | 27.0 | |
| CC | 92 | 27 | 31.4 | Met/Met | 191 | 62 | 27.6 | |
| P (trend)‡ | - | - | 0.14 | P (trend)‡ | - | - | 0.67 | |
| Postmenopausal | AA | 258 | 113 | 20.5 | Val/Val | 180 | 90 | 21.6 |
| No HRT use | AC | 186 | 98 | 23.1 | Val/Met | 225 | 104 | 21.7 |
| CC | 21 | 11 | 29.6 | Met/Met | 60 | 28 | 24.4 | |
| P (trend)‡ | - | - | 0.08 | P (trend)‡ | - | - | 0.57 | |
| Postmenopausal | AA | 228 | 97 | 29.2 | Val/Val | 176 | 81 | 29.3 |
| HRT use | AC | 192 | 88 | 30.4 | Val/Met | 192 | 79 | 30.8 |
| CC | 28 | 14 | 31.7 | Met/Met | 80 | 39 | 29.2 | |
| P (trend)‡ | - | - | 0.48 | P (trend)‡ | - | - | 0.88 | |
| BMI < 25 | AA | 504 | 157 | 34.2 | Val/Val | 412 | 135 | 35.4 |
| AC | 485 | 163 | 37.1 | Val/Met | 505 | 154 | 36.1 | |
| CC | 71 | 21 | 43.6 | Met/Met | 143 | 52 | 37.8 | |
| P (trend)‡ | - | 0.046 | P (trend)‡ | - | - | 0.53 | ||
| BMI >= 25 | AA | 359 | 128 | 19.2 | Val/Val | 276 | 94 | 19.0 |
| AC | 265 | 81 | 19.2 | Val/Met | 275 | 103 | 19.4 | |
| CC | 38 | 15 | 18.6 | Met/Met | 111 | 37 | 18.9 | |
| P (trend)‡ | - | 0.92 | P (trend)‡ | - | - | 0.96 | ||
*Percent densities were computed through mixed models using square-root transformed values while adjusting for age, BMI, case status, HRT use & type, ethnicity, parity, age at menarche, age at first live birth, family history of breast cancer, and menopausal status. Age, HRT use, and menopausal status are time-dependent variables.
# N is the number of mammograms used in the analysis; ## N is the number of subjects.
‡ P-values for a trend variable assigned the gene dosage effect using mixed models.