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. Author manuscript; available in PMC: 2007 Feb 19.
Published in final edited form as: J Burn Care Rehabil. 2004;25(4):337–345. doi: 10.1097/01.BCR.0000132168.02947.A1

Figure 5.

Figure 5

Proliferation of human endothelial cells after grafting is not enhanced in vascular endothelial growth factor (VEGF)-modified cultured skin substitutes plus endothelial cells (CSS + ECs). Sections were double-labeled with species-specific anti-CD31 antibodies to simultaneously localize mouse (A, C, E, G) and human (B, D, F, H) ECs. A and B. Control CSS + ECs (group 3) 1 week after grafting. C and D. VEGF-modified CSS + ECs (group 4) 1 week after grafting. E and F. Control CSS + ECs (group 3) 3 weeks after grafting. G and H. VEGF-modified CSS + ECs (group 4) 3 weeks after grafting. Dotted white lines indicate the locations of the dermal–epidermal junctions; sections are oriented with the epidermis at the top of each panel. In VEGF-modified CSS + ECs, relatively few human EC clusters (arrows) were observed in regions that were densely populated with mouse vessels (asterisks).