Fig. 2. TRPV1 desensitization knocked down by Cyanea capillata venom.
A. TRPV1 current during the first activation. The venom is added on the peak of this activation. B. Current during the first activation when the venom is added just at the time when desensitization is macroscopically visible. It can be seen that the venom quickly knocks down desensitization (see arrow). C. Trace showing the first and second activation of the channel and the effect of the venom when added during the second activation. Note that the venom restores exactly the desensitization-dependent fraction of the inward current (see arrow).