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. Author manuscript; available in PMC: 2007 Oct 16.
Published in final edited form as: FEBS Lett. 2006 Sep 22;580(24):5728–5732. doi: 10.1016/j.febslet.2006.09.030

Fig. 4. In vivo effect of Cyanea capillata venom with and without TRPV1 antagonist.

Fig. 4

A. Number of flinches during 4-minute observation period after left-hindpaw plantar injection of capsaicin (black) and vehicle (left diagonals). Pretreatment by subcutaneous injection of 40 mg/kg BCTC (white) or vehicle (right diagonals) and 1 hour later the number of flinches and bites were observed after an intraplantar injection of capsaicin (n=6). The effect of capsaicin with BCTC was significantly different from the effect of capsaicin alone. The BCTC vehicle did not give a significant difference as compared with capsaicin alone. B. Same tests as in A. Here, the effect of the venom was tested instead of capsaicin. The effect of venom with BCTC was significantly different from the effect of venom alone. The BCTC vehicle did not give a significant difference as compared with venom alone. In these experiments, the serum concentrations of anandamide or other endogenous TRPV1 activators were not determined.