Table 3.

Evidence for adaptive evolution of genes residing in the WFDC locus

M1 vs. M2, likelihood ratio test statistic for model M1 versus M2 (see Methods); M7 vs. M8, likelihood ratio test statistic for model M7 versus M8; M8 vs. M8a, likelihood ratio test statistic for model M8 versus M8a; lineage, likelihood ratio test statistic for variation in the d_N/d_S ratio among lineages; parameter estimates, the proportion of amino acids predicted to be under adaptive evolution (and their corresponding d_N/d_S ratio), with all data from model M8; sites under positive selection, individual amino acid positions found to be under positive selection with P > 0.95 (for full listing, see Supplemental Table S2); s, the tree length; d_N/d_S, the d_N/d_S ratio averaged across all sites and lineages; and N, number of primate species with sequences in alignment; lc, length of the alignment given as the number of codons (or amino acids); NA, not applicable since positive selection is not a significantly better fit to the data than the neutral model.

^aSignificance with P < 0.05.

^bSignificance with P < 0.001.