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. 2007 Mar;17(3):387–399. doi: 10.1101/gr.5893307

Figure 1.

Figure 1.

Integrated meiotic linkage map of the silver fox (Vulpes vulpes). Each linkage group corresponding to a fox chromosome (VVU1 through VVU16 and VVUX) is presented on the left side of each panel and aligned with the corresponding segments of the 7.6x dog genome sequence (CanFam2.0). Lines connect markers mapped onto the fox meiotic linkage map and identified in the assembly of the dog genome. Markers in plain format map to unique locations with confidence ≥1000:1 (LOD ≥3.0). Boxed markers were placed to unique locations with confidence ≥100:1 (LOD ≥2). Markers in italics are drawn in their most likely position, determined at the latter confidence threshold. Genetic distances between markers were calculated using the Kosambi mapping function. In general, most dog chromosomes each map to a single fox chromosome. Dog chromosomes which have their homologs divided among more than one fox chromosome are marked by asterisks (*) (see VVU1, 2, 4, 5, and 13). Dog chromosomal segments for which the orientation on the fox meiotic map was reversed compared to the orientation reported in previous cytogenetic studies (Graphodatsky et al. 2002) are marked by dots (●) (see VVU3, 4, 6, 8, and 12). Centromere positions of dog chromosomes are indicated in accordance with the dog genome sequence, assuming that the centromere is located at the beginning of each chromosome. Where different fragments of a single dog chromosome correspond to different fox chromosomal segments, a tilde (∼) indicates the breakage point along the dog chromosome. Positions of markers in the dog sequence are indicated in accordance with the CanFam2.0 assembly, except for REN315H04 and AHTH91. In the present study, marker REN315H04 mapped to VVU2 in a region corresponding to CFA2, which is in agreement with the Breen et al. (2001) and Guyon et al. (2003) canine maps, and CanFam1.0 assembly of the canine genome (chr2:84,742,789–84,742,951). The CanFam2.0 assembly, however, locates REN315H04 on CFA9 (chr9:21,100,622–21,100,777). Marker AHTH91 was identified only in the CanFam1.0 assembly.