Table 1.

Sequences of the five M1 RNA tetraloops and the mutations made in these tetraloops

Mutant designation	Wild-type sequence (5′ to 3′) [nucleotides]	Mutant sequence (5′ to 3′)
L3m	UUCG [39–42]	GAAA
L9m	GAAA [111–114]	UCCG
L9A111m	GAAA [111–114]	AAAA
L12m	GCAA [157–160]	UUCG
L14m	GUAA [212–215]	UCCG
L14A212m	GUAA [212–215]	AUAA
L14G214m	GUAA [212–215]	GUGA
L18m	GCGA [314–317]	UUCG
L18A316m	GCGA [314–317]	GCAA

Changed nucleotides in loop sequence are in bold and italics.