Abstract
WIN 51711 (5-[7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3-methylisoxazole), a new antipicornavirus drug, is a potent inhibitor of human entero- and rhinoviruses at concentrations not inhibitory to HeLa cell growth. In plaque reduction assays, WIN 51711 reduced plaque formation by 9 enteroviruses and 33 rhinoviruses, with MICs of 0.004 to 0.17 and 0.004 to 6.2 micrograms/ml, respectively. Addition of WIN 51711 to infected cells at concentrations of 0.02 to 5.0 micrograms/ml reduced the yield of picornaviruses by 90%. Other RNA viruses (nonpicornaviruses) and DNA viruses were unaffected by the compound.
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Selected References
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- Kim K. S., Sapienza V. J., Carp R. I. Antiviral activity of arildone on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother. 1980 Aug;18(2):276–280. doi: 10.1128/aac.18.2.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuhrt M. F., Fancher M. J., Jasty V., Pancic F., Came P. E. Preliminary studies of the mode of action of arildone, a novel antiviral agent. Antimicrob Agents Chemother. 1979 Jun;15(6):813–819. doi: 10.1128/aac.15.6.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKinlay M. A., Miralles J. V., Brisson C. J., Pancic F. Prevention of human poliovirus-induced paralysis and death in mice by the novel antiviral agent arildone. Antimicrob Agents Chemother. 1982 Dec;22(6):1022–1025. doi: 10.1128/aac.22.6.1022. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McSharry J. J., Caliguiri L. A., Eggers H. J. Inhibition of uncoating of poliovirus by arildone, a new antiviral drug. Virology. 1979 Sep;97(2):307–315. doi: 10.1016/0042-6822(79)90342-8. [DOI] [PubMed] [Google Scholar]
- Melnick J. L. Portraits of viruses: the picornaviruses. Intervirology. 1983;20(2-3):61–100. doi: 10.1159/000149376. [DOI] [PubMed] [Google Scholar]
- Wentworth B. B., French L. Plaque assay of Herpesvirus hominis on human embryonic fibroblasts. Proc Soc Exp Biol Med. 1969 Jun;131(2):588–592. doi: 10.3181/00379727-131-33932. [DOI] [PubMed] [Google Scholar]
- Wilfert C. M., Lehrman S. N., Katz S. L. Enteroviruses and meningitis. Pediatr Infect Dis. 1983 Jul-Aug;2(4):333–341. doi: 10.1097/00006454-198307000-00019. [DOI] [PubMed] [Google Scholar]