Table 1.

Mouse chemokines and their receptors. Chemokines can be classified into two major subfamilies differing in the position of two of four highly conserved cysteines. In CXC chemokines, the two N-terminal cysteines are separated by a single amino acid, whereas in CC chemokines these two cysteines are not separated. Exceptions to this classification are chemokines that lack two of the four mentioned cysteines (XC chemokines) and CX3CL1, in which three amino acids separate both cysteines. Alternatively, chemokines can be divided according to their expression patterns. Homeostatic chemokines, for example CCL21 and CXCL13, are expressed constitutively in secondary lymphoid organs, whereas inflammatory chemokines, such as CXCL9/10, are often associated with inflamed tissue.⁸⁶ No mouse homologues have been found so far for the human chemokines CCL13, CCL14, CCL15, CCL18, CCL23, CXCL8 and the receptors CXCR1 and CXCR3b. Interactions between chemokines and their CKR which are inferred from the human system but not tested directly in the murine system are not shown in this table

Chemokine	Receptor
CC chemokine/receptor family
CCL1	CCR8
CCL2	CCR2
CCL3	CCR1, CCR5
CCL4	CCR5
CCL5	CCR1, CCR3, CCR5
CCL61	CCR1?
CCL7	CCR1
CCL8	CCR3
CCL91	CCR1
CCL101	Unknown
CCL11	CCR3
CCL121	CCR2
CCL16	CCR1
CCL17	CCR4
CCL19	CCR7
CCL20	CCR6
CCL21	CCR7
CCL22	CCR4
CCL24	CCR3
CCL25	CCR9
CCL26	CCR3
CCL27	CCR10
CCL28	CCR3, CCR10
CXC chemokine/receptor family
CXCL1	CXCR2
CXCL2	CXCR2
CXCL3	CXCR2
CXCL4	Unknown
CXCL5	CXCR2
CXCL6	CXCR2
CXCL7	CXCR2
CXCL9	CXCR3
CXCL10	CXCR3
CXCL11	CXCR3
CXCL12	CXCR4
CXCL13	CXCR5
CXCL14	Unknown
CXCL151	Unknown
CXCL16	CXCR6
XC chemokine/receptor family
XCL1	XCR1
XCL2	XCR1
CX3C Chemokine/receptor family
CX3CL1	CX3CR1

¹Mouse chemokines with no known human homologues.