Figure 2.

Expression of activation markers on ovalbumin (OVA) T-cell receptor (TCR) transgenic (tg) CD4⁺ T cells from different lymphoid organs at different time-points following oral antigen administration. BALB/c mice received 4 × 10⁶ KJ1·26⁺ cells from naïve DO11·10 donors and were given an OVA-containing diet or a control diet. Transgenic CD4⁺ T cells from different lymphoid compartments of the OVA-fed mice were analysed for the expression of the activation markers (a) CD69, (b) CD25 and (c) CD122, at intervals following antigen introduction. For simplicity, measurements for the different compartments of the non-fed control mice are presented as a mean value, as no differences were detected amongst the organs. The data are presented as mean values (n = 4–6) and the error bars indicate the standard error of the mean (SEM). Statistic analyses were performed with the Mann–Whitney U-test. PP, Peyer's patch; MLN, mesenteric lymph node; CLN, celiac lymph node; PLN, peripheral lymph node.