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Induction of VEGF mRNA by the hypoxia mimetic deferoxamine (DFO) in the presence of polyamides 11, 12, 23 and 24 measured by quantitative real-time PCR. Polyamides 11 and 12, which bind the 5′-ATACGT-3′ sequence found in the VEGF HRE, show inhibition of DFO-induced VEGF expression. Polyamides 23 and 24, which target 5′-WGGWCW-3′, have a more modest effect. Concentrations of polyamides are 0.2 and 1 μM.
