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. 2006 Dec 14;35(2):414–423. doi: 10.1093/nar/gkl1060

Figure 2.

Figure 2

SECIS elements in viral glutathione peroxidases. (A) SECIS structures. Left structure, fowlpox virus GPx4 SECIS element. Middle structure, canarypox virus GPx4 SECIS element. Right structure, H.sapiens GPx4 SECIS element. SECIS core and unpaired AA nucleotides in apical loop are shown in boldface. (B) Location of viral GPx4 SECIS elements within mRNAs and comparison with GPx4 genes from other sources. Cys-containing GPx4 homologs from higher plants lack a SECIS element. In the human Sec-containing GPx4, SECIS element is in the 3′-UTR. In the fowlpox virus Sec-containing GPx4 homolog, SECIS element is the in the coding region. In the canarypox virus Cys-containing GPx4, a fossil SECIS element is in the coding region. Location of Cys is shown in white and Sec in black. SECIS elements are indicated by light-gray boxes and ORFs by dark-gray boxes. Left and right black lines represent 5′- and 3′-UTRs, respectively.