Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Design of SECIS elements in the coding regions of mammalian selenoprotein genes. (A) Designed GPx1 SECIS element. (B) Designed GPx4 SECIS element. The first amino acids (methionine), Sec, and the SECIS elements are shown in boldface. The amino acids that were mutated to accommodate the designed SECIS elements are highlighted. The newly introduced residues are shown by gray circles, and further changes in the designed GPx1 SECIS are shown by white circles.
