Abstract
The ionophore antimicrobial agents provide evidence that perturbations of the electrolyte balance of bacterial cells exert a growth-inhibitory activity. Several drugs acting on animal cell membranes have also been shown to be active on bacterial cells. In this paper, we report preliminary susceptibility studies showing that the class of potassium-sparing diuretics acting directly on monovalent cation fluxes on animal cells possesses a selective growth-inhibitory activity on hemolytic streptococci.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Giunta S., Pieri C., Groppa G. Amiloride, a diuretic with in vitro antimicrobial activity. Pharmacol Res Commun. 1984 Aug;16(8):821–829. doi: 10.1016/s0031-6989(84)80058-2. [DOI] [PubMed] [Google Scholar]
- Giunta S., Sampaoli G., Galeazzi L., Bilei L., Rinaldi R., Groppa G. Inhibition of nonspecific streptococcal coagglutination reactions. J Clin Microbiol. 1983 Feb;17(2):192–194. doi: 10.1128/jcm.17.2.192-194.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koch K. S., Leffert H. L. Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation. Cell. 1979 Sep;18(1):153–163. doi: 10.1016/0092-8674(79)90364-7. [DOI] [PubMed] [Google Scholar]
- Lubin M., Cahn F., Coutermarsh B. A. Amiloride, protein synthesis, and activation of quiescent cells. J Cell Physiol. 1982 Nov;113(2):247–251. doi: 10.1002/jcp.1041130210. [DOI] [PubMed] [Google Scholar]
- Pieri C., Giunta S., Giuli C., Bertoni-Freddari C., Muzzioli M. In vitro block of murine L 1210 leukemia cell growth by amiloride, an inhibitor of passive Na+ influx. Life Sci. 1983 Apr 11;32(15):1779–1784. doi: 10.1016/0024-3205(83)90842-1. [DOI] [PubMed] [Google Scholar]