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. 2007 Feb 21;104(9):3243–3248. doi: 10.1073/pnas.0611510104

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© 2007 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 2. — Defects in vascular remodeling in VE-PTP^Lz/Lz embryos. (A–F) Whole-mount PECAM-1-stained E9.5 embryos. VE-PTP^Lz/+ (A, C, and E) compared with a VE-PTP^Lz/Lz littermate (B, D, and F). (C and D) A closeup of the head vasculature shows the normal remodeling pattern of veins (blue arrows) and arteries (red arrows) in VE-PTP^Lz/+ embryos (C). In VE-PTP^Lz/Lz embryos, the venous plexus (blue arrows) undergoes only minor remodeling (D). (E and F) Closeup of the cardinal vein (blue arrows), which does not form correctly in VE-PTP^Lz/Lz embryos (F). (G and H) PECAM-1 immunostaining of E9.0 embryo cross sections at heart level. The dorsal aortas (red arrows) are small and collapsed in VE-PTP^Lz/Lz embryos (H) compared with WT (G), and the cardinal veins (blue arrows) are diffuse and not clearly delineated.