Table 2.
Category | Functional role | Examples |
I. Stemness | Recognized markers of stemness | Oct3/4, Nanog, Tdgf1 |
Candidate markers of stemness | Cpxm1, Hook1, Ddx21 | |
Germ cell markers | Rif1, Bnc1, Bnc2 | |
Hematopoietic stem cell markers | Hoxb4, Cdcp1, C1qr1 | |
Mesenchymal stem cell marker | Bmpr1a, Bmpr2, Cd49a | |
II. Proliferation | Proliferation markers | Ki67, Pcna, Myc |
Neural proliferation markers | Emx1, Gbx2 | |
III. Development | Differentiation | Lifr, Ebaf, Lyar |
Neuronal differentiation | Ren, Rai1, Neurod2 | |
Dopaminergic differentiation | Dlx1, Dlx2, Lmx1a | |
Neuronal maturation | Mecp2, Ebf3, Sox4 | |
Neuronal process formation | Hmgb1, Rage | |
Axonal elongation and branching | Pi3, Map1b, Slit1 | |
IV. Neural markers | Pan-neural markers | Gap43, Nfh, Eno2 |
Markers of dopaminergic neurons | Th, Aadc, Dat | |
Markers of cholinergic neurons | Ngf | |
Markers of spinal neurons | Hoxc6 | |
Glial markers | S100β, Cd68 | |
Astrocyte markers | Gfap, Tapa1 | |
Oligodendrocyte markers | Mag, Mobp, Omg | |
V. Distinct markers | Normal tissues | |
Liver | Gata6, G6pd, Fabp1 | |
Pancreas | Tff3, Sst, Pax4 | |
Skeletal muscle | Itga7, Dmd, Tnnt3 | |
Cardiac muscle | Nkx2.5, Anf, Myhca | |
Smooth muscle | Actg2, Cnn1, Sm22α | |
Endothelial cells | Flt1, Vwf, Pecam1 | |
Blood cell subtypes | Cd4, Cd8, Cd19 | |
Cancer cells | Maspin | |
Pancreatic cancer | Kras2 | |
Colon cancer | Mina53 | |
Breast cancer | Klk7 | |
Prostatic cancer | Hpn, Mat8 | |
Lung cancer | Rab5a, Tp63 | |
Ovarian cancer | Mgb2 | |
Hodgkin's lymphoma | Ptp4a, Atf5, p21snft | |
VI. Relevant groups | Apoptosis-related | p53, Psip1, Birc2 |
Telomere-related | Tert, Terf2, Rap1 | |
Antioxidants | Sod1, Sod2, Gpx1 | |
Imprinted genes | Tseb3, Gnas1, Grb10 | |
FZD group | Fzd1, Fzd3, Sfrp1 | |
WNT group | Wnt1, Wnt7a, Wisp1 | |
BMP group | Bmp1, Bmp2, Bambi | |
STAT group | Stat1, Stat3, Pias1 | |
FGF group | Fgf1, Fgf2, Fgfr4 | |
GDF group | Gdf2, Gdf3, Gdf9 | |
Caspases group | Casp1, Casp2, Hsp70 | |
Cyclins group | Ccna1, Ccnc, Cdk1 | |
Kruppel-like group | Klf2, Klf9, Znf184 |
Due to functional redundancy, individual genes may fit into more than one category.