Table 4.
Association of the CRS score (CRS ≤ 20; CRS > 20) with NAT2 genotype stratified by gender.
| Gene | Genotype | CRS ≤ 20 n (%) | CRS > 20 n (%) | Univariate odds ratio (95% CIa) | Multivariateb odds ratio (95% CI) | Pc |
| Females (n = 298) | ||||||
| NAT2 fast | *4/*4 | 9 (6.8) | 7 (4.2) | 1.00d | 1.00d | |
| *4/*5 | 40 (30.1) | 30 (18.2) | 0.96 (0.32–2.88) | 0.97 (0.32–2.91) | 0.958 | |
| *4/*6 | 24 (18.0) | 22 (13.3) | 1.18 (0.38–3.70) | 1.18 (0.37–3.70) | 0.780 | |
| *4/*7 | 2 (1.5) | 3 (1.8) | 1.93 (0.25–14.89) | 2.01 (0.26–15.56) | 0.505 | |
| NAT2 slow | *5/*5 | 19 (14.3) | 35 (21.2) | 2.37 (0.76–7.37) | 2.38 (0.76–7.42) | 0.136 |
| *5/*6 | 29 (21.8) | 43 (26.1) | 1.91 (0.64–5.69) | 1.93 (0.64–5.77) | 0.241 | |
| *5/*7 | 2 (1.5) | 3 (1.8) | 1.93 (0.25–14.88) | 1.92 (0.25–14.84) | 0.533 | |
| *6/*6 | 8 (6.0) | 21 (12.7) | 3.38 (0.94–12.14) | 3.44 (0.95–12.44) | 0.059 | |
| *6/*7 | - | 1 (0.6) | n.c.e | n.c.e | - | |
| *7/*7 | - | - | - | - | - | |
| NAT2 fast | all | 75 (56.4) | 62 (37.6) | 1.00d | 1.00d | |
| NAT2 slow | all | 58 (43.6) | 103 (62.4) | 2.15 (1.35–3.42) | 2.16 (1.35–3.44) | 0.001 |
| Males (n = 223) | ||||||
| NAT2 fast | *4/*4 | 6 (5.2) | 6 (5.6) | 1.00d | 1.00d | |
| *4/*5 | 28 (24.3) | 19 (17.6) | 0.68 (0.19–2.42) | 0.68 (0.19–2.52) | 0.568 | |
| *4/*6 | 15 (13.0) | 12 (11.1) | 0.80 (0.20–3.13) | 0.73 (0.18–2.95) | 0.662 | |
| *4/*7 | 1 (0.9) | 2 (1.9) | 2.00 (0.14–28.41) | 1.45 (0.10–21.03) | 0.786 | |
| NAT2 slow | *5/*5 | 30 (26.1) | 26 (24.1) | 0.87 (0.25–3.02) | 0.93 (0.26–3.34) | 0.905 |
| *5/*6 | 27 (23.5) | 31 (28.7) | 1.15 (0.33–3.98) | 1.18 (0.33–4.24) | 0.798 | |
| *5/*7 | 2 (1.7) | 2 (1.9) | 1.00 (0.10–9.61) | 0.95 (0.09–9.65) | 0.963 | |
| *6/*6 | 6 (5.2) | 10 (9.3) | 1.67 (0.37–7.61) | 1.61 (0.33–7.76) | 0.555 | |
| *6/*7 | - | - | - | - | - | |
| *7/*7 | - | - | - | - | - | |
| NAT2 fast | all | 50 (43.5) | 39 (36.1) | 1.00d | 1.00d | |
| NAT2 slow | all | 65 (56.5) | 69 (63.9) | 1.36 (0.79–2.33) | 1.45 (0.82–2.56) | 0.199 |