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. 2007 Feb 23;3(2):e22. doi: 10.1371/journal.ppat.0030022

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© 2007 Chun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Protein domains as predicted by SMART (http://smart.embl-heidelberg.de) for C. neoformans Sre1, Scp1, and Stp1. Transmembrane segments for Sre1 were predicted using MEMSAT3 (http://bioinf.cs.ucl.ac.uk). Arrowhead indicates site of 3×FLAG insertion into Sre1. bHLH, bHLH DNA-binding domain; peptidase, peptidase M50 family domain.

(B) ClustalW sequence alignment between C. neoformans Sre1 and its orthologs in C. albicans, Ustilago maydis, S. pombe, and human (SREBP-1A), depicting a portion of the predicted DNA-binding domain. All five contain a conserved tyrosine residue (indicated by asterisk) specific to the SREBP family of bHLH transcription factors.

(C) Domains as predicted by SMART for Tco1 homologs. C. neoformans Tco1, and orthologs to Tco1 from B. dermatiditis, H. capsulatum, C. albicans, and Neurospora crassa. HATPase, histidine kinase ATPase domain; HisKA, histidine kinase A domain; REC, cheY-like homologous receiver domain.