Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Feb 8;2:4. doi: 10.1186/1750-1326-2-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007 Vetrivel et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Model depicting the dual role of p23 in APP trafficking and processing. Our results suggest that p23 has dual roles in the negative regulation of APP metabolism. First, the function of p23/p24 family proteins in early secretory trafficking of proteins at the ER-Golgi boundary influences APP biogenesis in a manner that stabilizes nascent APP, as well as enhances APP maturation and steady-state accumulation at the cell surface. Second, p23 can modulate Aβ production by influencing the proteolysis of APP CTF by modulation of γ-secretase. Cells transfected with p23 siRNA secrete increased levels of Aβ. Moreover, absence of p23 expression also results in increased Aβ generated by proteolysis of recombinant APP CTF substrate in cell free assays, providing strong support for the notion that this latter function occurs independent of vesicular trafficking.