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Mutation rates in the P. vivax DHFR enzyme. (A) Mutation rate in individual PVDHFR codons. (B) Prevalence rate of the total number of mutations in PVDHFR. (C) Prevalence rates of the PVDHFR genotypes. The amino acid sequence (mutated amino acids are in boldface type) shown in the lower panel corresponds to PVDHFR codons 57, 58, 61, 93, and 117.
