TABLE 1.
In vitro activity of caspofungin and amphotericin B, alone and in combination, by the broth dilution assay against three Candida parapsilosis isolatesa
| Reading parameter | Drug(s) | Geometric mean (range) MIC (μg/ml) at time (h):
|
|
|---|---|---|---|
| 24 | 48 | ||
| IC50 | CAS | 0.79 (0.5-1.0) | 1.17 (0.5-4.0) |
| AMB | 0.16 (0.125-0.25) | 0.18 (0.06-0.5) | |
| CAS-AMB | 0.016b/0.07c (0.007-0.5/0.06-0.125) | 0.02b/0.09c (0.007-0.5/0.06-0.25) | |
| IC90 | CAS | 1.36 (0.5-4.0) | 2.33 (1.0-4.0) |
| AMB | 0.34 (0.125-1.0) | 0.68 (0.125-1.0) | |
| CAS-AMB | 0.06b/0.13c (0.007-1.0/0.03-0.25) | 0.12b/0.25c (0.007-1.0/0.03-0.5) | |
a
Each isolate was tested in quintuplicate.
b
P < 0.05 versus CAS alone.
c
P < 0.05 versus AMB alone.