TABLE 2.
In vitro activity of caspofungin and amphotericin B, alone and in combination, by disk diffusion assay against three Candida parapsilosis isolatesa
| Reading time (h) | Drugb | Halo diam (mm [mean ± SD]) with treatmentb:
|
|||
|---|---|---|---|---|---|
| AMB 0 | AMB 0.1 | AMB 1 | AMB 10 | ||
| 24 | CAS 0 | Not detectable | 6.7 ± 1.4 | 11.1 ± 1.8 | 15.2 ± 2.0 |
| CAS 1 | 6.2 ± 0.2 | 8.1 ± 2.1c | 13.4 ± 3.1c | 16.4 ± 3.2c | |
| CAS 10 | 13.3 ± 2.3 | 13.4 ± 0.9d | 16.3 ± 2.2c,d | 17.3 ± 2.7c | |
| CAS 100 | 21.1 ± 3.7 | 19.8 ± 1.7d | 22.0 ± 2.1d | 22.1 ± 1.9d | |
| 48 | CAS 0 | Not detectable | 6.4 ± 1.3 | 10.6 ± 0.8 | 13.7 ± 1.5 |
| CAS 1 | 6.1 ± 0.1 | 6.2 ± 0.7 | 12.8 ± 1.4c,d | 15.4 ± 1.6c,d | |
| CAS 10 | 13.2 ± 1.7 | 13.0 ± 0.7d | 15.2 ± 0.8c,d | 15.8 ± 0.8c,d | |
| CAS 100 | 21.2 ± 2.9 | 20.1 ± 2.8d | 21.8 ± 0.8d | 22.3 ± 1.6d | |
a
Each isolate was tested in triplicate.
b
CAS, caspofungin at 1 μg (CAS 1), 10 μg (CAS 10), and 100 μg (CAS 100); AMB, amphotericin B at 0.1 μg (AMB 0.1), 1 μg (AMB 1), and 10 μg (AMB 10).
c
P < 0.05 versus CAS alone.
d
P < 0.05 versus AMB alone.