FIG. 3.

Phenotypic susceptibilities of population isolates from patients with virologic rebounds. Population phenotypes of baseline and rebound isolates were determined as described in Materials and Methods. (A) ETV EC₅₀s for isolates from patients at baseline and the time of rebound (Rb); (B) fold change in ADV susceptibilities of rebound isolates. Open circles, patient isolates with WT or LVDr-encoding sequences at the time of rebound; filled circles, patient isolates with ETVr-encoding substitutions at the time of rebound. The median ADV susceptibilities (EC₅₀s) at the baseline and the time of rebound were both 2.7 μM. Isolates from patient 158 were not tested for their susceptibilities to ADV.