FIG. 4.

HBV DNA profiles for patients with virologic rebounds while receiving ETV. Patient HBV DNA levels over time are shown for patients exhibiting virologic rebounds while receiving ETV. Patient isolates had sequence evidence of ETVr-encoding substitutions at baseline (A), substitutions that emerged by Week 48 (B), substitutions that emerged by Week 96 (C), or no ETVr-encoding substitutions or reduced ETV susceptibility (D). Time points marked with a boxed X in panel D represent off-treatment visits.