TABLE 5.
Sequence analysis of isolates from rebound patients
| Patient no. | Phylogenic genotypea | Baseline substitutionsb | Rebound substitutionsb (wk) | Additional resistance substitutionsb (wk) |
|---|---|---|---|---|
| 251 | D | L180M, M204I/V, T184T/S | L180M, M204V, I169I/T, T184T/S/F/C (82) | S202S/G (98) |
| 122 | C | L180M, M204M/V, T184T/I | V173V/M, L180M, M204V, I169I/M, T184T/I/M/S, S202S/G (84) | |
| 001 | D | L180M, M204V, T184T/S | L180M, M204V, T184G, S202I (76) | I169I/T (92) |
| 069 | C | L180L/M, M204I/V | L180M, M204V, S202S/G (36) | T184T/A (48) |
| 256 | A | L180L/M, M204M/V | L180M, M204V, T184T/S/A (48) | |
| 113 | D | L180M, M204I | L180M, M204V, S202G (68) | |
| 174 | B | L180M, M204V | L180M, M204V, S202S/G (68) | |
| 204 | C | L180L/M, M204I | L180L/M, M204I/V, T184I/L (96) | |
| 007 | D | L180M, M204V | V173V/M, L180M, M204V, T184T/A (64) | |
| 130 | C | L180M, M204M/V | L180M, M204V, S202S/G (65) | T184T/I/M (80) |
| 163 | D | L180L/M, M204I/V | L180L/M, M204I/V, T184T/S (66) | L180M, M204V, T184T/S/A, S202S/G (94) |
| 235 | D | L180M, M204V | L180M, M204V, S202G (85) | |
| 162 | D | L180M, M204V, S202G (90) | ||
| 386 | D | L180L/M, M204I | L180M, M204V, S202G (66) | |
| 136 | C | M204I | L180M, M204V, S202G (100) | |
| 206 | C | L180M, M204V | L180M, M204V, T184T/L/F/M (77) | |
| 055 | C | L180L/M, M204I/V | L180M, M204I/V (36) | |
| 224 | C | (36) | ||
| 310 | C | M204I | M204I (51) | |
| 277 | D | (60) | ||
| 051 | D | (68) | ||
| 058 | B | L180L/M, M204I/V | L180M, M204V (68) | |
| 401 | D | L180L/M, M204I | L180L/M, M204I (88) | |
| 169 | A | L180M, M204V | L180M, M204V (89) | |
| 314 | D | M204M/I | M204I (96) | |
| 158 | B | L180M, M204V | L180M, M204V (84) |
a
The phylogenetic HBV genotype was determined from the alignments of the RT sequences.
b
The substitutions noted are primary LVDr-encoding substitutions at L180 and M204; secondary LVDr-encoding substitutions at V173; primary ETVr-encoding substitutions at T184, S202, and M250; and secondary substitutions at I169.