TABLE 2.
Average change (n-fold) in genes encoding chemokines as detected by cDNA arraysa
| Gene | Description | Fold change in THP-1 cells treated with A. fumigatus hyphae
|
|
|---|---|---|---|
| In the absence of VRC | In the presence of VRC | ||
| CCL2 | Chemokine (C-C motif) ligand 2 | −2.8 | −2.4 |
| CCL3 | Chemokine (C-C motif) ligand 3 | 1.1 | 19.3 |
| CCL4 | Chemokine (C-C motif) ligand 4 | 2.5 | 5.2 |
| CCL5 | Chemokine (C-C motif) ligand 5 | 1.5 | 17.7 |
| CCL7 | Chemokine (C-C motif) ligand 7 | 0.7 | 11.3 |
| CCL11 | Chemokine (C-C motif) ligand 11 | 1.9 | 2.5 |
| CCL15 | Chemokine (C-C motif) ligand 15 | 0.7 | 10.1 |
| CCL16 | Chemokine (C-C motif) ligand 16 | 2.5 | 0.04 |
| CCL20 | Chemokine (C-C motif) ligand 20 | 0.04 | −2.5 |
| CCL21 | Chemokine (C-C motif) ligand 21 | 0.2 | −2.6 |
| CXCL6 | Chemokine (C-X-C motif) ligand 6 | 0.08 | 3.5 |
| CXCL13 | Chemokine (C-X-C motif) ligand 13 | 1.3 | 7.0 |
a
Genes with a ≥2.5-fold increase in expression are defined as being up-regulated; genes with a ≥2.5-fold decrease in expression are defined as being down-regulated (indicated with minus signs); genes with changes (n-fold) less than the boundary values in either direction are considered to be not significantly changed.