TABLE 2.
MICs for linezolid-resistant clinical isolates of S. aureus and enterococci
| Species and strain no. | Heterozygous (Rr) or homozygous (RR) for G2576U | Source | MIC (μg/ml) of:
|
|
|---|---|---|---|---|
| RWJ-416457 | Linezolid | |||
| E. faecalis | ||||
| H0 4450-0446 | Rr | London, United Kingdom | 2 | 8 |
| 1 (L2) | Rr | Austria | 16 | 32 |
| 25 | Rr | Southeast United Kingdom | 16 | 32 |
| 37 | Rr | Midlands, United Kingdom | 8 | 32 |
| 45 | Rr | Southeast United Kingdom | 8 | 32 |
| 9 | Rr | Austria | 16 | 64 |
| E. faecium | ||||
| H0 5114-0276 | Rr | East Anglia, United Kingdom | 2 | 8 |
| 28 | Rr | London | 8 | 16 |
| 44 | Rr | Scotland | 4 | 16 |
| H0 4418-0062 | Rr | London, United Kingdom | 16 | 32 |
| 18 | Rr | Southeast United Kingdom | 8 | 32 |
| 31 | Rr | London | 8 | 32 |
| 2 (L1) | RR | Austria | 32 | 64 |
| 3 | Rr | Austria | 16 | 64 |
| 16 | RR | United States | 16 | 64 |
| 34 | RR | Dublin, Ireland | 32 | 64 |
| H0 4136-0043 | rra | Dublin, Ireland | 16 | 64 |
| MRSA | ||||
| H0 4536-0367 | Rr | Southeast United Kingdom | 2 | 8 |
| H0 4280-0256 | Rr | Midlands, United Kingdom | 4 | 16 |
| H0 4536-0368 | Rr | Southeast United Kingdom | 8 | 32 |
| H0 4280-0257 | Rr | Midlands, United Kingdom | 8 | 32 |
| H0 4280-0258 | Rr | Midlands, United Kingdom | 8 | 32 |
| B2 (posttherapy) | Rr | Brazil | 8 | 32 |
a
This strain has a novel mechanism of resistance.