TABLE 3.

MICs and mutations of linezolid-selected laboratory mutants of S. aureus

Strain or mutant	23S rRNA mutation	MIC (μg/ml) for:
		RWJ-416457	Linezolid
RN4220 (parent)		0.5	2
RN4220	G2447T	8	16
RN4220	G2576U	4	16
RN4220 ΔmutS (parent)		0.5	2
RN4220 ΔmutS	G2576U	8	16
RN4220 ΔmutS (revertant)	G2576U	8	16
RN4220 ΔmutS	G2576U, A2503G	8	32
ST/02/2121 (parent)		1	2
ST/02/2121	T2504C	8	16
ST/02/2121	G2447T	4	16