TABLE 1.
Micafungin population pharmacokinetic parameter estimates in mice
| Parametera | Mean | SD |
|---|---|---|
| Vc (liter) | 0.0068 | 0.0020 |
| SCL (liter/h) | 0.0008 | 0.0002 |
| Ka (h−1) | 4.4418 | 3.0669 |
| K12 (h−1) | 2.2494 | 1.0800 |
| K21 (h−1) | 19.6142 | 5.5527 |
| K13 (h−1) | 2.9619 | 1.4910 |
| K31 (h−1) | 25.4929 | 4.2651 |
a
Vc, volume of the central compartment (compartment 1); SCL, serum clearance; Ka, absorption constant from peritoneum into compartment 1; K12 and K21, transfer constant from compartment 1 to 2 (kidney) and vice versa; K13 and K31, transfer constants from compartment 1 to 3 (peripheral tissues) and vice versa.