FIG. 1.

Cumulative mortality of CD-1 mice infected intrathecally with 30 viable arthroconidia of C. immitis and given cyclodextrin (control), itraconazole, or fluconazole at the indicated doses. Therapies (Rx) were given BID by gavages on days 3 to 14 of infection. Five mice in each treatment group were randomly selected and euthanized on day 16 of infection for the quantitation of tissue burdens. n, numbers of mice per group; P < 0.001 (either treatment) versus the results for the control (log rank test).