FIG. 3.

Scattergram plot of individual CFU burdens on day 28 postinfection in the brains, spinal cords, and lungs of mice with CM. Itraconazole, fluconazole, and cyclodextrin were given BID through days 3 to 14 of infection. For the analysis of the fungal burdens in the surviving animals, a value of 8 log₁₀ CFU/g was given to missing datum points (due to the death of the animal) (21, 27). Horizontal lines, median log₁₀ of numbers of CFU/g tissue; *, P < 0.001 versus the results for the control; †, P < 0.05 for the results for ICZ versus the results for FCZ at 25 mg/kg; ‡, P < 0.005 for the results for ICZ versus the results for FCZ at 25 mg/kg.