TABLE 3.
Differences in clinical and microbiological outcomes between each antibiotic treatment groupa
| Parameter | Result for:
|
P valueb | ||
|---|---|---|---|---|
| Ofloxacin compared with:
|
Ofloxacin-azithromycin compared with azithromycin | |||
| Ofloxacin-azithromycin | Azithromycin | |||
| Clinical failures (%) | 12.3 (−47.4, 28.3) | 18.8 (3.6, 34.0) | 6.4 (−7.9, 20.7) | 0.053 |
| Blood culture positive posttreatment (%) | 1.6 (−36.6, 39.8) | −0.6 (−41.3, 41.5) | 1.6 (−38.6, 38.2) | 0.818 |
| Fecal carriage immediately posttreatment (%) | 12.9 (1.4, 28.0) | 17.8 (7.6, 28.0) | 4.9 (−2.0, 11.8) | 0.006 |
| Fever clearance time (days) | 1.06 (−0.29, 2.41) | 2.44 (1.25, 3.63) | 1.38 (0.21, 2.55) | <0.001 |
| Duration of hospitalization after starting treatment (days) | 0.85 (−0.41, 2.11) | 1.04 (−0.003, 2.11) | 0.19 (−0.81, 1.18) | 0.166 |
| Fecal carriage during convalescence at any time during 6 mo follow-up period | −3.4 (−13.2, 6.6) | −0.2 (−9.1, 8.7) | 3.2 (−6.7, 13.1) | 0.908 |
a
Data are differences, and 95% CI are shown in parentheses.
b
Overall P value using chi-squared or log rank test.