TABLE 1.
Antibacterial activity of FR264205 against clinical isolates of P. aeruginosa
| Strain (no. of isolates) | Compound | MIC (μg/ml)
|
||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| P. aeruginosa (193) | FR264205 | 0.25-4 | 0.5 | 1 |
| CAZ | 0.125-128 | 2 | 16 | |
| IPM | 0.125-64 | 2 | 16 | |
| CIP | ≤0.0313->128 | 0.25 | 8 | |
| P. aeruginosa, CAZ | FR264205 | 1-4 | 2 | 4 |
| resistant (13) | CAZ | 32-128 | 64 | 128 |
| IPM | 1-32 | 16 | 32 | |
| CIP | 0.0625-64 | 2 | 64 | |
| P. aeruginosa, IPM | FR264205 | 0.5-1 | 0.5 | 1 |
| resistant, CAZ | CAZ | 1-16 | 4 | 16 |
| susceptible (35) | IPM | 16-64 | 16 | 32 |
| CIP | 0.0625-32 | 1 | 8 | |
| P. aeruginosa, CIP | FR264205 | 0.5-4 | 1 | 2 |
| resistant (30) | CAZ | 1-128 | 8 | 64 |
| IPM | 1-32 | 8 | 16 | |
| CIP | 4->128 | 8 | 64 | |