TABLE 3.
Antimicrobial activity of synthetic gallinacin-6 by broth microdilution method
| Microorganism | Resulta (μg/ml) for:
|
|||
|---|---|---|---|---|
| sGal-6
|
rGal-6
|
|||
| MIC | MBC | MIC | MBC | |
| Gram-negative | ||||
| Campylobacter jejuni | 64 | >128 | 64 | 128 |
| Salmonella enterica serovar Typhimurium | >128 | >128 | >128 | >128 |
| Escherichia coli | 64 | 64 | >128 | >128 |
| Pseudomonas aeruginosa | >128 | >128 | >128 | >128 |
| Gram-positive | ||||
| Clostridium perfringens | 8 | 8 | 8 | 8 |
| Streptococcus pyogenes | 64 | 64 | NDb | ND |
| Staphylococcus aureus | >128 | >128 | >128 | >128 |
| Bacillus cereus | >128 | >128 | <128 | >128 |
| Fungi | ||||
| Candida albicans | 8 | >128 | 32 | >128 |
| Saccharomyces cerevisiae | 8 | >128 | 32 | >128 |
a
Determination of MICs and MBC. Final concentrations of 0 to 128 μg/ml peptide were incubated with 106 CFU/ml (sGal-6) or 105 CFU/ml (rGal-6) of each bacterial or fungal strain. All assays were performed in triplicate.
b
ND, not determined.