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Intracellular accumulation of norfloxacin alone or combined with EPIs. Norfloxacin was used at one-quarter the MIC (16 μg/ml) alone (N) or combined with omeprazole (N+Om) and (a) reserpine (N+Res) or new derivatives 1a to 1d (N+1a-d) and (b) 1e and 1f (N + 1e-f) at 128 μg/ml. Intracellular accumulation of norfloxacin in (a) SA-1199 and (b) SA-1199B is shown.
