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Effect of the DNA damage signal transduction pathways on MPF. Curve 1: no DNA damage, k4 = k10 = 0; curve 2: Chk1 pathway is on, p53 pathways are off, k4 = 0.2, k10 = 0; curve 3: p53 pathways are on, Chk1 pathway is off, k4 = 0, k10 = 0.2; curve 4: both Chk1 and p53 pathways are on, k4 = k10 =0.2. Other parameters and initial conditions are the same as in Fig. 8.
