Table 2.
Genes from which correlation mosaics in Figure 3A were derived. Genes in this table show the highest level of correlation by DFA analysis comparing adult and cord blood monocytes.
Order in mosaic | Accession No. | Gene symbol | Description |
1 | NM_017614 | BHMT2 | Betaine-homocysteine methyltransferase 2 |
2 | NM_001651 | AQP5 | Aquaporin 5 |
3 | NM_020163 | LOC56920 | Semaphorin sem2 |
4 | NM_012343 | NNT | Nicotinamide nucleotide transhydrogenase |
5 | NM_000096 | CP | Ceruloplasmin (ferroxidase) |
6 | NM_005819 | STX6 | Syntaxin 6 |
7 | NM_052951 | C20orf167 | Chromosome 20 open reading frame 167 |
8 | NM_001348 | DAPK3 | Death-associated protein kinase 3 |
9 | X73502 | KRT20 | Cytokeratin 20 |
10 | NM_052887 | TIRAP | Toll-interleukin 1 receptor (TIR) domain-containing adapter protein |
11 | NM_019555 | ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 |
12 | NM_014380 | NGFRAP1 | Nerve growth factor receptor (TNFRSF16) associated protein 1 |
13 | NM_001272 | CHD3 | Chromodomain helicase DNA binding protein 3 |
14 | NM_005842 | SPRY2 | Sprouty homolog 2 (Drosophila) |
15 | NM_012332 | MT-ACT48 | Mitochondrial Acyl-CoA Thioesterase |
16 | BC015041 | VATI | Vesicle amine transport protein 1 |
17 | NM_003872 | NRP2 | Neuropilin 2 |
18 | NM_005849 | IGSF6 | Immunoglobulin superfamily, member 6 |
19 | NM_014323 | ZNF278 | Zinc finger protein 278 |
20 | NM_030674 | SLC38A1 | Solute carrier family 38, member 1 |
21 | NM_004153 | ORC1L | Origin recognition complex, subunit 1-like (yeast) |
22 | NM_005249 | FOXG1B | Forkhead box G1B |
23 | NM_021048 | MAGEA10 | Melanoma antigen, family A, 10 |
24 | M60502 | FLG | Filaggrin |
25 | NM_004997 | MYBPH | Myosin binding protein H |
26 | J05046 | INSRR | Insulin receptor-related receptor |
27 | M33987 | CA1 | Carbonic anhydrase I |
28 | D31886 | RAB3GAP | RAB3 GTPase-ACTIVATING PROTEIN |
29 | L24498 | GADD45A | Growth arrest and DNA-damage-inducible, alpha |
30 | L07590 | PPP2R3 | Protein phosphatase 2 (formerly 2A), regulatory subunit B" (PR 72), alpha isoform and (PR 130), bet |
31 | D87024 | IGLV4-3 | Immunoglobulin lambda variable 4-3 |
32 | L35848 | MS4A3 | Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) |
33 | M18216 | CEACAM6 | Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
34 | M11952 | TRBV7–8 | T cell receptor beta variable 7–8 |
35 | D89094 | PDE5A | Phosphodiesterase 5A, cGMP-specific |
36 | M77140 | GAL | Galanin |
37 | D13628 | ANGPT1 | Angiopoietin 1 |
38 | M81635 | EPB72 | Erythrocyte membrane protein band 7.2 (stomatin) |
39 | D89859 | ZFP161 | Zinc finger protein 161 homolog (mouse) |
40 | D26069 | CENTB2 | Centaurin, beta 2 |
41 | L10717 | ITK | IL2-inducible T-cell kinase |
42 | L04282 | ZNF148 | Zinc finger protein 148 (pHZ-52) |
43 | L41944 | IFNAR2 | Interferon (alpha, beta and omega) receptor 2 |
44 | M82882 | ELF1 | E74-like factor 1 (ets domain transcription factor) |
45 | L26339 | RCD-8 | Autoantigen |
46 | D87328 | HLCS | Holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) |
47 | D00943 | MYH6 | Myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) |
48 | D00099 | ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide |
49 | L36531 | ITGA8 | Integrin, alpha 8 |
50 | D42084 | METAP1 | Methionyl aminopeptidase 1 |
51 | M76766 | GTF2B | General transcription factor IIB |
52 | J04621 | SDC2 | Syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) |
53 | D31888 | RCOR | REST corepressor |
54 | L32832 | ATBF1 | AT-binding transcription factor 1 |
55 | D86981 | APPBP2 | Amyloid beta precursor protein (cytoplasmic tail) binding protein 2 |
56 | M94362 | LMNB2 | Lamin B2 |
57 | M54968 | KRAS2 | V-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog |
58 | D42046 | DNA2L | DNA2 DNA replication helicase 2-like (yeast) |
59 | D86964 | DOCK2 | Dedicator of cyto-kinesis 2 |
60 | D50683 | TGFBR2 | Transforming growth factor, beta receptor II (70–80 kD) |
61 | M96843 | ID2B | Striated muscle contraction regulatory protein |
62 | M61906 | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) |
63 | M12679 | HUMMHCW1A | Cw1 antigen |
64 | M63623 | OMG | Oligodendrocyte myelin glycoprotein |
65 | J04162 | FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor for (CD16) |
66 | L48516 | PON3 | Paraoxonase 3 |
67 | M54927 | PLP1 | Proteolipid protein1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) |
68 | D86973 | GCN1L1 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) |
69 | D43968 | RUNX1 | Runt-related transcription factor 1 (acute myeloid leukemia 1-aml1 oncogene) |
70 | L05500 | ADCY1 | Adenylate cyclase 1 (brain) |
71 | D80010 | LPIN1 | Lipin 1 |
72 | D50918 | SEPT6 | Septin 6 |
73 | D86988 | RENT1 | Regulator of nonsense transcripts 1 |
74 | M90391 | IL16 | Interleukin 16 (lymphocyte chemoattractant factor) |
75 | M62324 | MRF-1 | Modulator recognition factor I |
76 | L77565 | DGS-H | DiGeorge syndrome gene H |
77 | D86970 | TIAF1 | TGFB1-induced anti-apoptotic factor 1 |
78 | D38169 | ITPKC | Inositol 1,4,5-trisphosphate 3-kinase C |
79 | D87684 | UBXD2 | UBX domain-containing 2 |
80 | D84454 | SLC35A2 | Solute carrier family 35 (UDP-galactose transporter), member 2 |
81 | M97496 | GUCA2A | Guanylate cyclase activator 2A (guanylin) |
82 | M95585 | HLF | Hepatic leukemia factor |
83 | L38517 | IHH | Indian hedgehog homolog (Drosophila) |
84 | L20860 | GP1BB | Glycoprotein Ib (platelet), beta polypeptide |
85 | M26880 | UBC | Ubiquitin C |
86 | D86962 | GRB10 | Growth factor receptor-bound protein 10 |
87 | D63481 | SCRIB | Scribble |
88 | D17525 | MASP1 | Mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor) |
89 | L26584 | RASGRF1 | Ras protein-specific guanine nucleotide-releasing factor 1 |
90 | M65066 | PRKAR1B | Protein kinase, cAMP-dependent, regulatory, type I, beta |
91 | J05158 | CPN2 | Carboxypeptidase N, polypeptide 2, 83 kD |
92 | L36861 | GUCA1A | Guanylate cyclase activator 1A (retina) |
93 | L11239 | GBX1 | Gastrulation brain homeo box 1 |
94 | D90145 | SCYA3L1 | Small inducible cytokine A3-like 1 |
95 | M96739 | NHLH1 | Nescient helix loop helix 1 |
96 | M12959 | TRA@ | T cell receptor alpha locus |
97 | D80005 | C9orf10 | C9orf10 protein |
98 | M13231 | TRGC2 | T cell receptor gamma constant 2 |
99 | D28588 | SP2 | Sp2 transcription factor |
100 | M57732 | TCF1 | Transcription factor 1, hepatic-LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor |
101 | NM_014755 | TRIP-Br2 | Transcriptional regulator interacting with the PHS-bromodomain 2 |
102 | NM_000576 | IL1B | Interleukin 1, beta |
103 | NM_002089 | GRO2 | GRO2 oncogene |
104 | NM_002089x | GPRC5D | G protein-coupled receptor, family C, group 5, member D |
105 | NM_002713 | PPP1R8 | Protein phosphatase 1, regulatory (inhibitor) subunit 8 |
106 | NM_014383 | TZFP | Testis zinc finger protein |
107 | NM_012248 | SPS2 | Selenophosphate synthetase 2 |
108 | AL137438 | SEC15L | SEC15 (S. cerevisiae)-like |
109 | NM_005387 | NUP98 | Nucleoporin 98 kD |
110 | NM_003476 | CSRP3 | Cysteine and glycine-rich protein 3 (cardiac LIM protein) |