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The minimal cleavage domain of human Nup98 is evolutionarily conserved. The corresponding regions of the human (hs), rat (rn), Caenorhabditis elegans, A. thaliana, and S. cerevisiae proteins are aligned (GenBank accession numbers U41815, P49793, AAA91249, AAD32891, and P49687). Residues common to at least three of the organisms are highlighted. The cleavage site and HFS tripeptide are indicated.
