Table 4.
Adverse effects profile
| Carbetocin (n = 150) | Syntometrine (n = 150) | Mean difference | RR | 95% CI | |
|---|---|---|---|---|---|
| Nausea* | 2 (1.3) | 11 (7.3) | — | 0.18 | 0.04–0.78 |
| Vomiting* | 1 (0.7) | 10 (6.7) | — | 0.10 | 0.01–0.74 |
| Facial flushing* | 0 | 3 (2) | — | — | — |
| Headache* | 1 (0.7) | 2 (1.3) | — | 0.50 | 0.05–5.54 |
| Shivering* | 2 (1.3) | 6 (4) | — | 0.33 | 0.06–1.63 |
| Pain over injection site* | 0 | 1 (0.7) | — | — | — |
| Tachycardia (pulse ≥ 100 beats per minute) within 60 minutes postdelivery* | 32 (21.3) | 19 (12.7) | — | 1.68 | 1.03–3.57 |
| Mean systolic blood pressure immediately after delivery** | 113.7 (11.6) | 116.7 (12.9) | −3.0 | — | −5.7 to −0.2 |
| Mean diastolic blood pressure immediately after delivery** | 63.4 (9.2) | 67.2 (9.4) | −3.8 | — | −6.0 to −1.7 |
| Mean systolic blood pressure 30 minutes after delivery** | 112.9 (10.3) | 118.1 (11.6) | −5.2 | — | −7.8 to −2.8 |
| Mean diastolic blood pressure 30 minutes after delivery** | 64.5 (8.4) | 68.1 (10.0) | −3.6 | — | −5.7 to −1.5 |
| Mean systolic blood pressure 60 minutes after delivery** | 113.3 (10.5) | 117.1 (11.9) | −3.8 | — | −6.4 to −1.3 |
| Mean diastolic blood pressure 60 minutes after delivery** | 64.7 (8.7) | 67.9 (8.8) | −3.2 | — | −5.2 to −1.2 |
| Hypertension (blood pressure ≥ 140/90 mmHg)* | |||||
| Immediately after delivery | 2 (1.3) | 4 (2.7) | — | 0.5 | 0.09–2.74 |
| 30 minutes after delivery | 0 | 8 (5.3)*** | — | — | — |
| 60 minutes after delivery | 0 | 6 (4)**** | — | — | — |
*
Data are presented as n (%).
**
Data are presented as mean (SD).
***
P < 0.01 by Fisher‘s exact test.
****
P < 0.05 by Fisher’s exact test.