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. 1999 Sep 28;96(20):11382–11386. doi: 10.1073/pnas.96.20.11382

Figure 2.

Figure 2

Conditional expression of the mutant DTS5 proteasome subunit results in fate transformation. (A) Cuticle of a wild-type adult. (B–D) Sense organ cells in a 24-hr-APF A101/TM6b pupa. The socket cell is marked with Su(H) in green (B), the sheath cell with Prospero (pros) in blue (C), and all the sense organ cells with β-galactosidase in red in the merged view (D). (E) cuticle of a sca-gal4; UAS-DTS5/TM6b pharate adult. The bristle phenotype exhibited by these sca-DTS5 flies was stronger than the one observed in DTS5 heterozygous pupae, suggesting that larger amount of mutant subunits were produced in the former ones. (F–H) Sense organ cells in a 24-hr-APF sca-gal4/+; UAS-DTS5/A101 pupa. Staining is as in B–D. (I–L) Sense organ cells in a 24-hr-APF A101/TM6b (I, J) or sca-gal4/+; UAS-DTS5/A101 pupa (J). Sense organ cells are marked with β-galactosidase (in green; I and K) and nonneuronal cells express a higher level of Ttk69 (in red; J and L). In all panels, anterior is up, and the notum midline is on the right side in B–D and F–L.