Table IV.
Selected virologic characteristics of novel human CD8 Ags in vaccinia
| OREa | Functionb | Kinetic Classb |
|---|---|---|
| A3L | Major core protein | Late (39) |
| A23R | Transcription factor | Early (40) |
| A24R | DNA-dependent RNA polymerase | Early-int-late (41) |
| A48R | Thymidylate kinase/synthase | Early (42) |
| A50R | DNA ligase, virulence | Early (43) |
| A57R | Guanylate kinase homolog (21) | Unknown |
| C12L | Serine protease inhibitor- like (44) | Unknown |
| D1R | mRNA capping enzyme subunit (45) | Early (46) |
| D5R | Nucleoside triphosphatase, role in DNA replication (47) | Unknown |
| E3L | ss RNA binding, immune evasion (48) | Early (49) |
| F3 | Unknown; previously not documented to encode protein | Unknown |
| F12L | Infectious enveloped virus protein; extracellular enveloped virus formation, virulence | Early and late (50) |
| I3L | ssDNA binding protein (51) | Early (52) |
| IL-18bp | Immune evasion (53) | Early (38) |
| M2L | Unknown | Early (54) |