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. Author manuscript; available in PMC: 2007 Dec 29.
Published in final edited form as: Cell. 2006 Dec 29;127(7):1361–1373. doi: 10.1016/j.cell.2006.10.043

Figure 5. 53BP1 Localization to Sites of DNA DSBs Is Mediated by the Interaction between 53BP1 Tandem Tudor Domains and Dimethylated Lys20 of Histone H4.

Figure 5

53BP1 relocalization (53BP1) in irradiated 53BP1 null MEFs transiently transfected with 53BP1 wild-type (WT) or 53BP1 mutated in the H4-K20me2-binding cage. Sites of DNA DSBs were marked by costaining using anti-phosphorylated-H2AX (Ser139) (P-H2AX) antibody.