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Expression of normal length (25Q) and extended (104Q) polyglutamine constructs in single COS-1 cells shown at high magnification. (A) Normal length (25Q) naked construct shows diffuse cytoplasmic expression pattern. (B) Extended polyglutamine construct (104Q) aggregates in the cytoplasm. Diffuse, presumably soluble material is not seen in cells with aggregates. (C) 104Q/TBP shows multiple aggregates within the nucleus. (D) 104Q/nucleolin shows a single nucleolar aggregate.
