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PDGF-induced chemotaxis is reduced in mutant fibroblasts. Chemotactic response of wt or mutant cells toward no ligand (□) or 10 ng PDGF-BB (■) was tested by using either the “Transwell”- (A) or the “Neuroprobe”-modified Boyden Chamber assay (B; see Materials and Methods). Fold induction values are added above the bars for SD. Results from one representative experiment are shown.
