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. 2006 Oct 31;6(Spec No A):S163–S177. doi: 10.1102/1470-7330.2006.9037

Table 1.

Classification of pancreatic neuroendocrine tumours [25, 16]

Tumour Frequency Syndrome Pancreatic Hormone Malignant Anatomical Typical
name (%) islet cell produced (%) location size
Insulinoma 50 Insulinoma B cell Insulin 10–15 Pancreas >90% (head = body = tail) <2 cm 90%, <1 cm 40%
Gastrinoma 20–30 Zollinger–Ellison syndrome G cell Gastrin 60–75 Pancreas 30%–60% a, duodenum 30%–40% a, lymph nodes 10%–15% a, other <5 0.3–3.0 cm
Non-functioning and PPoma 15–30 No syndrome D1 cell None or pancreatic polypeptide 60–90 Pancreas (most frequently in the head) Large
VIPoma 3 Verner–Morrison syndrome; WDHA D2 cell Vasoactive intestinal peptide 50–80 Pancreas 90% (usually tail), adrenal 10% Large
Glucagonoma Rare Glucagonoma A cell Glucagon 60 Pancreas 2–10 cm
Somatostatinoma Rare Somatostatinoma b D cell Somatostatin 50–70 Pancreas 56%, jejunum 44% Large

a 90% are within the gastrinoma triangle. b Somatostatinoma may be associated with NF 1.