Table 2.
Representative subset of proteins identified by mass spectrometry
| Cell type | ORF19a | C. albicans gene | S. cerevisiae homologb | Description of functionc |
|---|---|---|---|---|
| Bud | 5759 | SNQ2 | SNQ2 | ABC transporter protein involved in multidrug resistance |
| 1415 | FRE10 | FRE1 | Cell-surface ferric reductase | |
| 4118 | CNT | None | Cation-coupled nucleoside transporter | |
| 3765 | RAX2 | RAX2 | Transmembrane protein involved in bipolar bud site selection | |
| 7001 | — | YCK1,2 | Casein kinase I | |
| Germ tube | 7094 | HGT12 | SNF3 | MFS superfamily glucose sensor/transporter |
| 4335 | TNA1 | TNA1 | Nicotinic acid transporter | |
| 2614 | RSR1 | RSR1 | RAS-related protein | |
| 176 | OPT4 | OPT2 | Oligopeptide transporter | |
| 7030 | SSR1 | CCW14 | GPI anchor protein with a role in cell wall structure | |
| Both | 5383 | PMA1 | PMA1,2 | Plasma membrane H(+)-ATPase |
| 4456 | GAP4 | GAP1 | Putative amino acid permease; hyphal induced | |
| 3829 | PHR1 | GAS1,2 | GPI-anchored glycoside; role in cell wall structure | |
| 3646 | CTR1 | CTR1 | Copper transporter | |
| 1760 | RAS1 | RAS1,2 | RAS signal transduction GTPase |
a Open reading frame designation from ORF19 release of the C. albicans genome database.
b Closest homolog found in the S. cerevisiae genome.
c Function as indicated by experimental work or by close similarity to known genes in other organisms.